Open AccessDownregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo
Author(s) -
Junkai Chang,
Weihua Xu,
Guangchao Liu,
Xiang Du,
Xiaodong Li
Publication year - 2017
Publication title -
oncology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 57
eISSN - 1555-3906
pISSN - 0965-0407
DOI - 10.3727/096504016x14742891049118
Subject(s) - downregulation and upregulation , rab , cancer research , gli1 , prostate cancer , in vivo , cancer , cell growth , biology , microbiology and biotechnology , medicine , gtpase , signal transduction , hedgehog signaling pathway , biochemistry , gene
Rab23, a novel member of the Rab GTPase family, was found to be implicated in the progression of some human cancers. However, what role Rab23 plays in prostate cancer (PCa) remains to be illustrated. In the present study, we investigated the expression pattern and roles of Rab23 in PCa. The study results showed that Rab23 was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 remarkably suppressed the proliferation, migration, and invasion of PCa cells. In addition, downregulation of Rab23 significantly downregulated the protein expression levels of Shh and Gli1. Furthermore, we found that the Gli1 inhibitor GANT-61 greatly enhanced the suppressive effect of Rab23 downregulation on PCa cells. In conclusion, we suggested Rab23 as a potential therapeutic target for PCa treatment.