Open AccessThermal Radiofrequency Ablation as an Adjuvant Therapy for Patients With Colorectal Liver Metastasis
Author(s) -
Yun Fan,
Xiyan Zhu,
Qiuping Lan,
Fang Lou,
Yu Zheng,
Hongbo Lou,
Yong Fang,
Wei Jin,
Hong-Ming Pan,
Kaifeng Wang
Publication year - 2016
Publication title -
oncology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 57
eISSN - 1555-3906
pISSN - 0965-0407
DOI - 10.3727/096504016x14567549091260
Subject(s) - medicine , radiofrequency ablation , univariate analysis , hazard ratio , proportional hazards model , multivariate analysis , metastasis , lesion , colorectal cancer , ablation , adjuvant therapy , gastroenterology , radiology , surgery , cancer , confidence interval
Radiofrequency ablation (RFA) is a minimally invasive technology for the treatment of liver malignancies and is used as an adjuvant therapy in patients with colorectal liver metastasis (CLM). This study enrolled a total of 49 CLM patients who underwent RFA treatment. Univariate and multivariate analyses were performed using the log-rank test and Cox proportional hazard model, respectively. Univariate analysis showed that OS was closely correlated with tumor size, frequency of RFA treatment, resection of the liver lesion, and CEA levels before RFA (p < 0.05). Multivariate analysis revealed that resection of CLM lesions after RFA, frequency of RFA treatment, and serum CEA levels before RFA were independent risk factors for the survival of CLM patients (p < 0.05). Tumor lesion size, resection of the liver lesion after RFA, frequency of RFA treatment, and serum CEA levels before RFA may be important prognostic factors of CLM patients treated with RFA therapy.