Open AccessAEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer
Author(s) -
Li C,
Xiaoqing Wu,
W Zhang,
Jian Li,
Liu H,
Mu Hao,
Jin Wang,
Hengtian Zhang,
Guoliang Yang,
Shoupeng Sheng,
Yue Sun,
Long Jiang,
Xiaoyun Hu,
Chen Hu,
Li L,
Jiasheng Zheng
Publication year - 2015
Publication title -
oncology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 57
eISSN - 1555-3906
pISSN - 0965-0407
DOI - 10.3727/096504015x14386062091352
Subject(s) - metastasis , liver cancer , cancer research , cancer , mechanism (biology) , biology , medicine , philosophy , epistemology
Liver cancer is one of the most lethal cancers, but our knowledge of the molecular mechanism underlying this process remains insufficient. Through deep sequencing and expression regulation analysis in liver cancer cells, we identified two novel factors, AKR1C2 (positive factor) and NF1 (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer. They were experimentally validated to have the capacities of regulating cell migration, cell invasion, cell proliferation, and EMT. Further clinic expression and animal model evidence confirmed their functions. Together, our findings provide a new insight into the pharmaceutical and therapeutic use of AEG-1 and downstream AKR1C2 and NF1.