Open Access程序性坏死及其在关节炎病理机制和治疗中的作用
Author(s) -
Zhichao Liu,
Zhouyang Qian,
Yingnan Wang,
Huiming Wang
Publication year - 2022
Publication title -
zhejiang daxue xuebao. yixue ban
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.14
H-Index - 13
ISSN - 1008-9292
DOI - 10.3724/zdxbyxb-2021-0402
Subject(s) - necroptosis , osteoarthritis , inflammation , pathogenesis , medicine , cartilage , programmed cell death , disease , articular cartilage , joint disease , mechanism (biology) , kinase , cancer research , immunology , bioinformatics , apoptosis , pathology , biology , microbiology and biotechnology , anatomy , genetics , alternative medicine , philosophy , epistemology
Osteoarthritis is a progressive degenerative joint disease induced by many causes, for which there is no radical cure currently. Necroptosis is a newly reported programmed cell death, and its related factors are also inseparable from the progress of osteoarthritis. For examples, damage-associated molecular pattern promotes the release of various inflammatory factors, so as to recruit macrophages and promote local inflammation of the joint; inhibition of receptor-interacting protein kinase can reduce the death of cell and the expression of inflammatory factors, so as to reduce cartilage damage. Therefore, in-depth study of the regulatory mechanism of necroptosis in osteoarthritis will help to further reveal the pathogenesis of osteoarthritis, so as to provide potential targets for the treatment of osteoarthritis.