Open AccessProgress on mitochondrial silence information regulator family in epilepsy
Author(s) -
Feng Zhu,
Yingchun Xiang,
Linghui Zeng
Publication year - 2021
Publication title -
zhejiang daxue xuebao. yixue ban
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.14
H-Index - 13
ISSN - 1008-9292
DOI - 10.3724/zdxbyxb-2021-0163
Subject(s) - sirtuin , microbiology and biotechnology , biology , epileptogenesis , sirt3 , mitochondrion , mitochondrial dna , regulator , cell metabolism , neuroscience , epilepsy , cell , genetics , acetylation , gene
SIRT3, SIRT4 and SIRT5 are located in mitochondria and also known as mitochondrial sirtuins. They play important roles in regulating many cellular functions including cell survival, cell cycle or apoptosis, DNA repair and metabolism. Mitochondrial sirtuins are involved in the protection of mitochondrial integrity and energy metabolism under stress regulating the expression of neurotransmitter receptors, neurotrophins, extracellular matrix proteins and various transcription factors, thus involved in epileptogenesis triggered by both genetic or acquired factors. Here we review research progress on the actions of mitochondrial sirtuin in epilepsy; and discuss the challenges and perspectives of mitochondrial sirtuin as a potential therapeutic target for epilepsy.