Open AccessThe role of neutrophils in asthma
Author(s) -
Fei Chen,
Min Yu,
Yueyang Zhong,
Wen Huang,
Huaqiong Huang
Publication year - 2021
Publication title -
zhejiang daxue xuebao. yixue ban
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.14
H-Index - 13
ISSN - 1008-9292
DOI - 10.3724/zdxbyxb-2021-0030
Subject(s) - immunology , asthma , eosinophil , medicine , airway , myeloperoxidase , inflammation , chemokine , neutrophil elastase , elastase , chemotaxis , pathophysiology of asthma , antibody , granulocyte , receptor , biology , enzyme , biochemistry , surgery
Bronchial asthma is a chronic respiratory diseasecharacterized by airway inflammationairway hyperresponsivenessreversible airway obstruction and airway remodelingin which a variety of cells including airway inflammatory cells and structural cells are involved. Previous studies have shown that asthma is mainly driven by Th2 cytokines IL-4IL-5and IL-13leading to airway eosinophil inflammation. With further researchhoweverit has been found that neutrophils are also closely related to asthma. Numbers of neutrophils are elevated in airway through increased chemotaxis and decreased apoptosiswhich is earlier than eosinophilsleading to airway neutrophilic inflammation. Neutrophils can produce elastasemyeloperoxidaseneutrophil extra- cellular trapschemokines and cytokinesparticipating in the occurrence and development of asthma. The antagonists against these moleculessuch as anti-IL-8 receptor antibodyanti-IL-17 antibodyand DNasehave shown positive effects on neutrophilic asthmabut further studies are needed to support their clinical application. This article mainly reviews the role of neutrophils in asthma and related mechanisms.