Open AccessLocomotor activity and learning and memory abilities in Alzheimer’s disease induced by Aluminum in an acid environment in Zebrafish
Author(s) -
Xiong He,
Zhaoming Zhong,
Yi Che
Publication year - 2013
Publication title -
dongwuxue yanjiu
Language(s) - English
Resource type - Journals
ISSN - 0254-5853
DOI - 10.3724/sp.j.1141.2012.02231
Subject(s) - neurotoxicity , zebrafish , locomotor activity , neuroscience , psychology , chemistry , pharmacology , toxicity , medicine , biochemistry , gene , organic chemistry
We investigated the contribution of locomotor activity and learning and memory abilities to Alzheimer's disease induced by metal neurotoxicity. The metal neurotoxicity model was established by using locomotor activity tests and activity-avoidance conditioning paradigms, and observing changes in zebrafish behaviors after exposure to 50 μg/L of AlCl(3) with different pH values (pH 7.8, pH 6.8 and pH 5.8) for 24 hours and 96 hours. The results showed Alzheimer's disease-like behavior in locomotor activity tests and activity-avoidance conditioning paradigms by zebrafish receiving AlCl(3) in pH 5.8 significantly decreased compared to the control group and groups receiving AlCl(3) in pH 7.8 and pH 6.8 for 96 hours and 24 hours. These results provide evidences that exposure to AlCl( 3) in an acid environment can influence locomotor activity and learning and memory abilities in zebrafish. In addition, exposure time and concentration of Al induced neurotoxicity and damaged the brain area of memory, resulting in Alzheimer's disease-like behavior.