Open AccessRecent progress in multi-stage mass spectrometry-based quantitative proteomics
Author(s) -
Ying Zhang,
Pengyuan Yang,
Haojie Lu
Publication year - 2013
Publication title -
sepu/chinese journal of chromatography
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.171
H-Index - 19
eISSN - 1872-2059
pISSN - 1000-8713
DOI - 10.3724/sp.j.1123.2013.03056
Subject(s) - proteomics , quantitative proteomics , mass spectrometry , proteome , chromatography , quantitative analysis (chemistry) , chemistry , biochemistry , gene
With the development of proteome research, quantitative proteomics is becoming a very active area of proteomics research. The development of quantitative proteomics requires the advancement of a number of mass spectrometry (MS) -based quantitative techniques. According to the mass spectrometric stage at which the peptides are quantified, MS-based quantitative methods can be divided into two categories: MS(1) -based quantitation and MS(n)-based quantitation. In this review, the progress of MS(n)-based quantitation approaches is summarized and the advantages and disadvantages are compared. The trend of MS(n)-based quantitation is also prospected.