Open AccessZebrafishcellmovements during gastrulation
Author(s) -
Ting Zhang,
Xianming Mo
Publication year - 2013
Publication title -
yichuan
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 16
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2013.00441
Subject(s) - gastrulation , epiboly , microbiology and biotechnology , convergent extension , mesoderm , zebrafish , germ layer , polarity in embryogenesis , ectoderm , biology , endoderm , cell migration , wnt signaling pathway , epiblast , nodal signaling , embryo , cellular differentiation , embryogenesis , cell , embryonic stem cell , genetics , signal transduction , induced pluripotent stem cell , gene
During zebrafish gastrulation, large cellular rearrangements create the formation of the three germ layers, ectoderm, mesoderm, and endoderm. This process includes three types of conserved morphogenetic movement: epiboly, involution, and convergent extension. Specially, the anterior movement of prechordal plate progenitors is essential for the location and differentiation of mesendoderm progenitors, and the pechordal plate progenitors'coherent migration is thought to be a good model to study the mechanism of cell movement in vivo. Gastrulation migration is known to be controlled by many signaling pathways such as Wnt/planar cell polarity signaling; however, the underlying molecular mechanism for cellular behavior remains unknown. At present, it is generally agree that cell adhesion and cytoskeletal rearrangement are critical factors during zebrafish gastrulation cell migration. In addition, the role of extraembryonic tissue (yolk syncytial layer) during gastrulation is concerned increasingly. Here, we described the essential factors for controlling cellular behaviors and highlighted the major issues and questions that require further investigation during zebra fish gastrular cell migration in order to provide a complete map containing all the factors for regulating gastrulation cell migration and their interactions on a cellular level.