Open AccessPar polarity complex in mammalian neurogenesis
Author(s) -
Huiling Chen,
Xiaoping Chen
Publication year - 2013
Publication title -
yichuan
Language(s) - Uncategorized
Resource type - Journals
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2013.00281
Subject(s) - neurogenesis , polarity (international relations) , synaptogenesis , neocortex , cell polarity , microbiology and biotechnology , biology , neural stem cell , multicellular organism , neuroscience , mammalian brain , stem cell , cell , biochemistry
Mammalian neurogenesis is a highly complicated process with programmed morphology and function evolution. Polarity, a basic characteristic in neurogenesis, is controlled by regulating proteins such as the partition defective (Par) proteins. Par polarity complex is the most investigated Par protein among these polarity proteins. There are developmental dynamic changes during neurogenesis for the protein distribution and content, which are related to the junction establishment, polarity formation, synaptogenesis, and neuronal migration. Moreover, Par complex is considered to affect the developmental fate of neural precursors. This study summarizes the advances of the protein cellular location, function, and mechanism in embryal neocortex and cultured neuron.