Open AccessBioinformaticresearch of the family of PEX11, peroxisomeproliferous factor in fungus
Author(s) -
Xin Zhang,
Hua Jiang,
Yanli Wang,
Zhen Zhang,
Xueqin Mao,
Rongyao Chai,
Haiping Qiu,
Xinfa Du,
Jiaoyu Wang,
Guochang Sun
Publication year - 2012
Publication title -
yichuan
Language(s) - English
Resource type - Journals
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2012.00635
Subject(s) - phylogenetic tree , biology , fungus , ascomycota , evolutionary biology , gene , botany , genetics
The family members of PEX11 are key factors involved in regulation of peroxisome proliferation. Sixty-six PEX11p candidates of PEX11 gene family from 26 representative fungal species were obtained and analyzed by bioinformatic strategies. In most filamentous fungi, 2 or 3 potential PEX11ps were found, in contrast with 1 or 2 in yeast species. Compared with other fungal species, the Ascomycetes tend to have more PEX11ps, and even 5 in several individuals. The data of phylogenetic analysis and protein structure indicated that all of the PEX11ps were divided into 3 groups: I, II, and III. The members of group I and group III existed in most species, while those in group II were found only in Pezizomycotina. By MEME analysis, 5-6 conserved motifs were found in each PEX11ps. Among them,motif 8 in C-terminal had the most conservation, indicating that this motif probably plays a key role in maintaining the proper function of PEX11p.