Open AccessFunction of SM protein in vesicle transport
Author(s) -
Xiang Zhao,
Baoda Han,
Lixin Li
Publication year - 2012
Publication title -
yichuan
Language(s) - English
Resource type - Journals
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2012.00389
Subject(s) - snare complex , vesicle , munc 18 , microbiology and biotechnology , vesicle fusion , lipid bilayer fusion , vesicular transport protein , syntaxin , snap25 , transport protein , chemistry , function (biology) , stx1a , vesicular transport proteins , biology , cytoplasm , biochemistry , synaptic vesicle , membrane , vacuole , vacuolar protein sorting
Most cells contain various transport vesicles that target to different destinations. The underlying molecular mechanisms are highly conserved in evolution. Sec1/Munc-18 (SM) proteins play an important role on regulating vesicle transport by interacting with soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) at each vesicle fusion sites. SM proteins interact with syntaxin, an important component in SNARE complex, to regulate the assembly of SNARE complex, and promote overall membrane fusion process together with SNARE complex. This review summaries new research progresses of structure and function of SM protein.