Recent research progress of biogenesis and functions of miRNA* | Zendy

Shengyun Ma | Zendy; Yu Bai | Zendy; Ning Han | Zendy; Junhui Wang | Zendy; Xiaoyan Weng | Zendy; Hongwu Bian | Zendy; Muyuan Zhu | Zendy

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Recent research progress of biogenesis and functions of miRNA*

Author(s) -

Shengyun Ma,

Yu Bai,

Ning Han,

Junhui Wang,

Xiaoyan Weng,

Hongwu Bian,

Muyuan Zhu

Publication year - 2012

Publication title -

hereditas (beijing)

Language(s) - English

Resource type - Journals

ISSN - 0253-9772

DOI - 10.3724/sp.j.1005.2012.00383

Subject(s) - microrna , biogenesis , argonaute , rna interference , biology , computational biology , drosha , rna , gene silencing , microbiology and biotechnology , genetics , gene

MicroRNA*s are about 22nt noncoding RNAs, which are processed from precursors with a characteristic hairpin secondary structure in the biogenesis of microRNAs. Recently, miRNA* strands were shown to mediate post-transcriptional regulatory networks, rather than serve merely as non-functional by-product in general view. Unlike miRNAs bound to AGO1, miRNA* strands are bound to AGO2 to form RISC duplex to mediate RNAi, which is similar to siRNA. This paper mainly reviewed the recent research progresses on miRNA*, such as the biosynthesis, biological characteristics, and functions.

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