Open AccessThe genetic safety of induced pluripotent stem (iPS) cells
Author(s) -
Qian Chen,
Qinghua Shi
Publication year - 2012
Publication title -
yichuan
Language(s) - English
Resource type - Journals
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2012.00260
Subject(s) - induced pluripotent stem cell , stem cell , biology , microbiology and biotechnology , embryonic stem cell , genetics , gene
Since Takahashi and Yamanaka first generated induced pluripotent stem (iPS) cells from mouse fibroblasts successfully in 2006, iPS cells have rapidly become a new hotspot in the field of stem cells research because of their broad potential application prospects. Meanwhile, more and more attentions are paid to the genetic safety of iPS cells. This article summarizes recent findings on genetic safety of iPS cells and reviews the possible causes leading to genetic instability of iPS cells. Hopefully, this review is helpful to improve the induction of iPS cells and obtain genetically safe iPS cells.