Open AccessLength of cell cycle in neural development
Author(s) -
Juan Gu,
Xiaoping Chen
Publication year - 2011
Publication title -
yichuan
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 16
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2011.01185
Subject(s) - cell fate determination , cell cycle , microbiology and biotechnology , biology , cell , cyclin , neural development , cell division , neural cell , cell growth , notch signaling pathway , signal transduction , gene , genetics , transcription factor
Neural development of mammals generates a series of morphological and functional alterations in neural precursors. The precursors change the length of cell cycle in the process. Importantly, the changes are related to cell fate determination. Cellular and environmental factors have been elucidated including cyclin complex, notch signal pathway, proneural gene target proteins, microtubule and motor proteins. In the cell-cycle length hypothesis, cell cycle length could influence the accumulation of cell fate determinants in precursors, which decides the final cell fate of daughter cells. This study summarizes recent advances in the field.