Open AccessStructure, localizations and functions of chromosomal passengerStructure, localizations and functions of chromosomal passenger complex
Author(s) -
Jianrong Dai,
Huihua Zheng,
Ping Zhang
Publication year - 2011
Publication title -
yichuan
Language(s) - English
Resource type - Journals
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2011.00576
Subject(s) - aurora b kinase , centromere , kinetochore , cohesin , microbiology and biotechnology , sister chromatids , cytokinesis , spindle checkpoint , mitosis , chromatin , spindle apparatus , establishment of sister chromatid cohesion , biology , chromosome segregation , cell division , genetics , chromosome , cell , dna , gene
Chromosomal passenger complex (CPC) is mainly composed of a protein kinase Aurora B, inner centromere protein, Survivin, and Borealin. As in different periods of cell division, CPC can localise correctly to relavent destinations in time and interact on its different substrates in the mitotic cell. CPC modulats phosphorylation of histone H3 in chromatin aggregation and controlls cohesion or segregation of sister chromatids. It is involved in assembly of a mitotic spindle and its chromosomes catched. Moreover, CPC corrects attachment errors between kinetochore and microtuble and gives faithfuly chromosomal segregation and promoting cytokinesis. Here, the structure compenants, localization on chromosomal arms, inner centromere and central spindle, and functions in defferent posisions of CPC were briefly descriped.