Open AccessApplications of DNA transposons to the study of gene function in mice
Author(s) -
Lin Liu,
Meili Zhang,
Yue Huang
Publication year - 2011
Publication title -
yichuan
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 16
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2011.00485
Subject(s) - insertional mutagenesis , transposable element , mutagenesis , biology , genetics , gene , sleeping beauty transposon system , function (biology) , transgene , computational biology , forward genetics , dna transposable elements , transposon mutagenesis , dna , mutation , mutant
In the past decade, transposon-mediated insertional mutagenesis has been widely used in mammalian molecular genetics. As a convenient and efficient tool for genetic manipulation, transposon has played an important role in making transgenic animal models, performing gene therapy, and annotating gene function at the cellular level and by animal studies in vivo. This review focuses on the structure, function and latest research progress of DNA transposons applied in mouse genetics.