Applications of DNA transposons to the study of gene function in mice | Zendy

Lin Liu | Zendy; Meili Zhang | Zendy; Yue Huang | Zendy

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Applications of DNA transposons to the study of gene function in mice

Author(s) -

Lin Liu,

Meili Zhang,

Yue Huang

Publication year - 2011

Publication title -

hereditas (beijing)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 16

ISSN - 0253-9772

DOI - 10.3724/sp.j.1005.2011.00485

Subject(s) - insertional mutagenesis , transposable element , mutagenesis , biology , genetics , gene , sleeping beauty transposon system , function (biology) , transgene , computational biology , forward genetics , dna transposable elements , transposon mutagenesis , dna , mutation , mutant

In the past decade, transposon-mediated insertional mutagenesis has been widely used in mammalian molecular genetics. As a convenient and efficient tool for genetic manipulation, transposon has played an important role in making transgenic animal models, performing gene therapy, and annotating gene function at the cellular level and by animal studies in vivo. This review focuses on the structure, function and latest research progress of DNA transposons applied in mouse genetics.

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