Open AccessAn update on the development of transgenic animal technology
Author(s) -
Qingmiao Luo,
Xiangyang Miao,
Rui-Jie Zhang
Publication year - 2011
Publication title -
yichuan
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 16
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2011.00449
Subject(s) - transgene , induced pluripotent stem cell , biology , zinc finger nuclease , rna interference , gene transfer , somatic cell , gene , gene silencing , computational biology , microbiology and biotechnology , genetics , genome , embryonic stem cell , genome editing , rna
The animal transgenic technology has increasingly turned mature over several decades and promoted the research of transgenic technology to a new developmental phase. In this review, various kinds of transgenic technologies, including somatic cell nuclear transfer, gene transfer mediated by transposon, gene knockout mediated by RNA interference, and zinc-finger nucleases-gene targeting technology, are summarized. Recently, the success of induced pluripotent stem cells (iPS cells), which has provided an alternative way to derive pluripotent stem cells of large animals, will extend the field of transgenic animal studies. Here, we summarized the latest trends on the basis of previous studies. In addition, the characteristics of different kinds of transgenic methods in detail are discussed.