Open AccessATP-dependent chromatin remodeling complex and its function in regulating chromatin structure
Author(s) -
Rui Wang,
Xianlu Zeng
Publication year - 2010
Publication title -
yichuan
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 16
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2010.00301
Subject(s) - chromatin remodeling , chromatin , chromatin structure remodeling (rsc) complex , histone modifying enzymes , microbiology and biotechnology , histone , bivalent chromatin , chia pet , histone code , nucleosome , biology , chemistry , dna , genetics
The highly condensed chromatin prevents binding of transcription factors and cofactors to DNA. Therefore, it is crucial to relief the repressive environment for transcription through chromatin remodeling activities. Recently, it is widely accepted that chromatin remodeling is carried out by at least two mechanisms: ATP-dependent chromatin remodeling complex and covalent modifications of histone tails by histone modification complexes. This paper reviews the mechanisms of chromatin remodeling through ATP-dependent chromatin remodeling complex and how the two complexes work together to modify the chromatin structure and regulate the function of transcription mechanism according to recent studies.