Open AccessLow Volume High Intensity Interval Exercise affects Serum BDNF and proBDNF levels in Sedentary Healthy Men.
Author(s) -
Ramlah Farouk Muhammad,
Muhammed Mabrouk Elkashab,
Atif Amin Baig,
Salisu Ahmed Ibrahim
Publication year - 2021
Publication title -
asian journal of medicine and biomedicine
Language(s) - English
Resource type - Journals
ISSN - 2600-8173
DOI - 10.37231/ajmb.2021.5.2.434
Subject(s) - medicine , brain derived neurotrophic factor , endocrinology , neurotrophic factors , glycemic , insulin , receptor
Background: Exercise and dietary modifications help improve energy balance and glucose control. High intensity interval exercise (HIIE) induces an increase in serum brain-derived neurotrophic factor (BDNF) with a corresponding decrease in its precursor (proBDNF). Pro-BDNF, possesses biological activities opposite those of BDNF. However, only few reports on the effect of HIIE on proBDNF compared to extensive studies on the BDNF.
Methods: Normal, healthy, male adults performed six sessions of HIIE in a span of 2 weeks. Venous blood was collected, from which fasting blood sugar, glycated haemoglobin, serum insulin, BDNF and proBDNF were measured using ELISA.
Results: Marked decrease in markers of glycemic control were recorded following the intervention. A reduction in proBDNF and increase in BDNF was also observed post exercise. We found a strong negative relationship between BDNF and FBS post exercise.
Conclusion: HIIE reduces BDNF and proBDNF healthy men.