Open AccessPROX1 IMMUNOHISTOCHEMICAL ANALYSIS OF PEDIATRIC VASCULAR ANOMALIES, A POSIBLE PROGNOSTIC AND THERAPEUTIC FACTOR OF HEMANGIOMAS?
Author(s) -
Rodica Heredea,
Simona Cerbu,
Emil Radu Iacob,
Teodora Hoinoiu,
Maria Corina Stănciulescu
Publication year - 2020
Publication title -
jurnalul pediatrului
Language(s) - English
Resource type - Journals
eISSN - 2360-4557
pISSN - 2065-4855
DOI - 10.37224/jp.2020.9192.08
Subject(s) - infantile hemangioma , medicine , lesion , hemangioma , lymphatic system , therapeutic approach , immunohistochemistry , vascular tumors , pathology , disease
Infantile and congenital hemangiomas still a challenge for both the pediatric surgeon and the pediatrician. The treatment of hemangiomas must be individualized according to: the type of lesion, location, size, depth, stage of growth and evolution of the lesion. To date, none of the available therapies is considered standard therapy. Currently, personalized therapy is not widely applied in Romania, not being included in the usual therapy protocols in any of the types of hemangioma. This is a starting point for the identification of new specific therapeutic targets that preserve normal endothelial cells and determine the regression of hemangioma, especially recurrent ones and those with an increased proliferation rate. Another controversial and unexplained aspect, consequently unexploited from a therapeutic point of view is represented by the expression and role of lymphatic markers in infantile and congenital hemangiomas.