Open AccessEpidermal Growth Factor-Like Domain-8 (EGFL8) in Mammals: The Story so far
Author(s) -
Fazli Subhan,
Muhammad Naeem,
Wasim Sajjad,
Liaqat Ali,
Isfahan Tauseef,
Kashif Syed Haleem
Publication year - 2020
Publication title -
life and science
Language(s) - English
Resource type - Journals
eISSN - 2708-2970
pISSN - 2521-0475
DOI - 10.37185/lns.1.1.59
Subject(s) - epidermal growth factor , biology , microbiology and biotechnology , growth factor , signal transduction , domain (mathematical analysis) , vascular endothelial growth factor , cancer research , computational biology , neuroscience , genetics , receptor , vegf receptors , mathematical analysis , mathematics
Epidermal growth factor-like domain-8 (EGFL8) also known as vascular endothelial statin-2 (VE-statin-2). It was identified by using retroviral gene entrapment vectors, expressed in endothelial cells. It is located on chromosome6inhumansandchromosome17inthemouse. EGFL8codesaproteinof293aminoacidswithan amino-terminal signal peptide and has two EGF-like domains. EGFL8 plays a very important regulatory role in thymopoiesis, cell migration and invasion through the modulation of Notch signaling. Although the signaling regulatory factors of EGFL8 need to be explored but recent scientific advances have revealed some important aspect of its regulation. This review summarizes the current knowledge about all aspects of EGFL8 since its discovery.