Open AccessMagnesium in aging and aging-related disease
Author(s) -
Zhiguo Zou,
Qishao Lu,
Yifan Wang,
Xing Gao,
Xinye Zhu,
Xiyuan Lu,
Jun Pu
Publication year - 2022
Publication title -
stemedicine
Language(s) - English
Resource type - Journals
ISSN - 2705-1188
DOI - 10.37175/stemedicine.v3i2.119
Subject(s) - disease , oxidative stress , inflammation , apoptosis , transporter , biology , microbiology and biotechnology , medicine , bioinformatics , chemistry , endocrinology , biochemistry , immunology , gene
Magnesium (Mg2+) is an essential divalent cation in human body. Its balance is tightly controlled via a balanced interplay among intestinal absorption, storage, and renal excretion, involving multiple transporters across cell membrane that regulate Mg2+ influx and efflux. Mg2+ is involved in a variety of physiological and pathological processes such as enzymatic reactions, energy metabolism, cell proliferation, apoptosis, oxidative stress, and inflammation. In particular, Mg2+ contributes to the molecular hallmarks of aging. Emerging evidence demonstrates that altered Mg2+ status has been associated with many aging-related diseases, including cancer, cardiovascular disease, neurodegenerative disease, musculoskeletal function, metabolic syndrome, and COVID-19. In this review, we focus on Mg2+ and its association with molecular hallmarks of aging. We also summarize recent findings supporting an important role of Mg2+ in aging-related disease including the COVID-19 pandemic.