Open AccessHeterogeneity of mesenchymal stem cells: characterization and application in cell therapy
Author(s) -
Xingzhi Liu,
Zhihua Zhao,
Zhe Zhao,
Zhongjuan Xu,
Junjun Cao,
Bin Wang,
Guangli Suo
Publication year - 2022
Publication title -
stemedicine
Language(s) - English
Resource type - Journals
ISSN - 2705-1188
DOI - 10.37175/stemedicine.v3i1.109
Subject(s) - mesenchymal stem cell , immunogenicity , regenerative medicine , genetic heterogeneity , stem cell , computational biology , biology , immunology , phenotype , immune system , microbiology and biotechnology , genetics , gene
Mesenchymal stem cells (MSCs) have shown great potentials in regenerative medicine for their low immunogenicity, multilineage differentiation potential, and extensive sources. However, the heterogeneity of MSCs limits their clinical application and industrial prospects. In this review, we introduced the heterogeneity of MSCs in terms of their applications, sources, functions, and surface markers; discussed the major factors leading to the heterogeneity in MSCs; summarized the main approaches to study the MSC heterogeneity, and addressed the clinical challenges resulting from heterogeneity. Finally, we proposed the strategies that might be used to purify the MSCs and to eliminate the heterogeneity of MSCs for their standardized production and reliable clinical application.