Open AccessFisiopatologia e desenvolvimento do diabetes mellitus tipo 3 e sua relação com a doença de Alzheimer
Author(s) -
Giúlia Jäger Maximowicz de Oliveira,
Camila Luisa Roda Cichacewski,
Carolina Fantin Carneiro,
Letícia Fuganti Campos,
Antônio Carlos Ligocki Campos
Publication year - 2021
Publication title -
braspen journal
Language(s) - English
Resource type - Journals
eISSN - 2764-1546
pISSN - 2525-7374
DOI - 10.37111/braspenj.2020354015
Subject(s) - insulin resistance , type 2 diabetes , diabetes mellitus , medicine , context (archaeology) , insulin , type 2 diabetes mellitus , neurodegeneration , apolipoprotein e , neurocognitive , disease , alzheimer's disease , bioinformatics , endocrinology , cognition , biology , psychiatry , paleontology
Alzheimer’s disease (AD) is characterized by a progressive and persistent deterioration of the whole cognitive function, which results in an impaired cortical function. Some yearsago, the connection between AD and type 2 diabetes has been studied, resulting in the term type3 diabetes (T3D). Methods: This is a literature review, a search for articles published in the last5 years in the Medline and PubMed databases was performed, using the descriptor: Alzheimerdisease, diabetes, insulin resistance. Results: For analysis, 12 articles were selected, with 10literature reviews and 2 original studies. Among those who explored the cellular and molecularrelationship between AD and insulin resistance, possible pathogenic mechanisms, the role of insulinin the brain, environmental factors linked to AD and dietary interventions to prevent neurodegeneration. Conclusion: The relation between AD and type 2 diabetes is due several mechanismssuch as lipid metabolism, insulin metabolism and agents related to its functioning, like the ApoEε4,C-peptide, the glycogen synthase kinase 3β (GSK-3β) and the amyloid-beta (Aβ). It is suggestedthat several changes, mainly in insulin metabolism, can impair neurocognitive function and triggerAD. Future studies are needed to analyze the context of T3D and find possible treatments thatattenuate the AD progression and promote quality of life for the patients.