Open AccessAção da L-glutamina via oral por 7 dias na estrutura e função muscular de pacientes com HIV/AIDS em uso de terapia antirretroviral
Author(s) -
Cervantes Caporossi,
Camila da Silva Martins Ribas,
Diana Borges Dock-Nascimento,
Daniela de Brito Maurício
Publication year - 2020
Publication title -
braspen journal
Language(s) - English
Resource type - Journals
eISSN - 2764-1546
pISSN - 2525-7374
DOI - 10.37111/braspenj.2020351008
Subject(s) - glutamine , medicine , biceps , antiretroviral therapy , human immunodeficiency virus (hiv) , body weight , gastroenterology , viral load , surgery , immunology , biochemistry , biology , amino acid
Patients infected with the human immunodeficiency virus (HIV) have prolonged survival with the use of antiretroviral therapy (ART). The chronic evolution of the disease allows the appearance of changes in several systems, including nutritional impairment and muscular function. The objective of this study is to observe the action of orally administered L-glutamine on the skeletal muscles of patients with HIV/AIDS in chronic use of ART. Methods: Seropositive patients adhered to ART were divided into two groups: a) GG - glutamine group (n=10) and b) GM - maltodextrin group (n=9). The groups were supplemented orally and for 7 days, GG with 0.5 mg/kg/day of L-glutamine and GM with 0.5 mg/kg/day of maltodextrin. The analyzed variables were: parameters of muscle strength and muscle mass, evaluated by collection instruments, respectively, dynamometry and bioimpedance. Results: There was a reduction in body weight(p=0.043) and an increase in biceps strength (p=0.006) in GG. In GM, there was an increase in body weight, accompanied by gain of muscle mass and loss of fat amount, without causing significant changes in body mass index. Conclusion: L-glutamine, orally supplemented, for 7 days, increased the muscle strength of the biceps of seropositive patients taking ART.