Association of Serum Uric acid with Recent Ischaemic Stroke

Introduction: To evaluate association of serum uric acid with ischemic stroke patients and assess its relationship with cerebrovascular risk factors. Methods: This was a hospital based cross-sectional observational study conducted at TUTH between May 2016 to May 2017. A total 120 Patients eligible for the study criteria was enrolled for the study. Nonprobability convenience sampling was used for the sampling purpose. All patients ages 40 years or above 40 years with confirmed diagnosis of recent ischaemic stroke were included for the analysis. Results: Mean ages of the enrolled subjects were 60.63 years ± 11.11 SD and eighty three (69.2%) population were male. Sixty one (50.8%) subjects were smoker and twenty seven (22.5%) were alcoholic. Prevalence of hyperuricemia was 17.5%. Serum uric acid level values were higher in male(69.1%) than female(30.9) population..Higher levels of serum uric acid level were found in both male population who smoked and were alcoholic in contrast serum uric acid levels were higher in both female population who were non smoker and did not consume alcohol in comparison to male. .Likewise, both diabetic and dyslipidemic male and female had higher serum uric acid level in comparison to who were non diabetic and did not consume alcohol. The mean score of serum uric acid level in male and female were significa different (P=0.029). Similalry, serum uric acid level was significantly different in smoker and no-smoker group (p=0.049), hypertensive and non hypertensive (p=0.027) and dyslipidemic and non dyslipidemic group (p=0.005) Conclusions: Our study showed high prevalence of hyperuricemia in ischemic stroke patients and there was a potential link between serum uric acid and cerebrovascular risk factors, indicating possible role of uric acid as the risk factor of ischemic stroke. Keywords: cerebrovascular risk factor; Uric acid level, recent ischaemic stroke.