Open AccessFormulation and invitro evaluation of immediate release tablets containing febuxostat
Author(s) -
Sai Vamsi Krishna Dontala,
V Jhansi Priya Marabathuni,
Naidu Narapusetty
Publication year - 2022
Publication title -
upi journal of pharmaceutical, medical and health sciences
Language(s) - English
Resource type - Journals
ISSN - 2581-4532
DOI - 10.37022/jpmhs.v5i1.68
Subject(s) - febuxostat , croscarmellose sodium , granulation , excipient , compression (physics) , chemistry , chromatography , materials science , dosage form , composite material , magnesium stearate , uric acid , biochemistry , hyperuricemia
Febuxostat Immediate Release Tablet were prepared by direct compression method using varying concentrations of Lycoat, Crospovidone & Croscarmellose sodium as disintegrants. The formulations prepared were evaluated for Precompression& post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Febuxostat) and optimized formulation (Febuxostat + excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing 12mg of CCS shows 98.45% of the drug release within 40 min & follows first order kinetics.