Formulation and invitro evaluation of immediate release tablets containing febuxostat | Zendy

Sai Vamsi Krishna Dontala | Zendy; V Jhansi Priya Marabathuni | Zendy; Naidu Narapusetty | Zendy

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Formulation and invitro evaluation of immediate release tablets containing febuxostat

Author(s) -

Sai Vamsi Krishna Dontala,

V Jhansi Priya Marabathuni,

Naidu Narapusetty

Publication year - 2022

Publication title -

upi journal of pharmaceutical medical and health sciences

Language(s) - English

Resource type - Journals

ISSN - 2581-4532

DOI - 10.37022/jpmhs.v5i1.68

Subject(s) - febuxostat , croscarmellose sodium , granulation , excipient , compression (physics) , chemistry , chromatography , materials science , dosage form , composite material , magnesium stearate , uric acid , biochemistry , hyperuricemia

Febuxostat Immediate Release Tablet were prepared by direct compression method using varying concentrations of Lycoat, Crospovidone & Croscarmellose sodium as disintegrants. The formulations prepared were evaluated for Precompression& post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Febuxostat) and optimized formulation (Febuxostat + excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing 12mg of CCS shows 98.45% of the drug release within 40 min & follows first order kinetics.

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