Open AccessDevelopment and validation of new analytical method for the simultaneous estimation of Netupitant and Palonosetron in bulk and pharmaceutical dosage form
Author(s) -
Pushpa Divya P,
RajKumar. Kudari
Publication year - 2021
Publication title -
upi journal of pharmaceutical, medical and health sciences
Language(s) - English
Resource type - Journals
ISSN - 2581-4532
DOI - 10.37022/jpmhs.v4i4.38
Subject(s) - palonosetron , mathematics , chromatography , chemistry , medicine , nausea , antiemetic
A simple, Accurate, precise method was developed for the simultaneous estimation of the Netupitant and Palonosetron in pharmaceutical dosage form. Retention time of Palonosetron and Netupitant were found to be 2.266 min and 2.805 min. %RSD of the Netupitant and Palonosetron were and found to be 0.8 and 1.1 respectively. %Recovery was obtained as 100.08% and 100.15% for Netupitant and Palonosetron respectively. LOD, LOQ values obtained from regression equations of Netupitant and Palonosetron were 1.63, 4.94 and 0.003, 0.010. respectively. Regression equation of Netupitant is y =11553x + 9661.and y = 51072x + 152.0. of Palonosetron. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.