Open AccessSynthesis, antibacterial activities, binding mode analysis and predictive ADME studies of novel 1-(aryl)-2-(1H-imidazol-1-yl)methanones
Author(s) -
Priyanka Chandra,
Swastika Ganguly,
Rajdeep Dey,
Bikash Kanti Sarkar
Publication year - 2020
Publication title -
international journal of pharmaceutical education and research
Language(s) - English
Resource type - Journals
ISSN - 2582-2152
DOI - 10.37021/ijper.v2i2.2
Subject(s) - adme , aryl , chemistry , elemental analysis , antibacterial activity , proton nmr , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , in vitro , bacteria , alkyl , biology , genetics
In the present study a novel series of twelve 1-(aryl)-2-(1H-imidazol-1-yl)methanones 3(a-l) were synthesized and characterised by physicochemical and spectral analysis,viz. elemental analysis, IR spectroscopy, NMR spectroscopy. The antibacterial property of the compounds were examined, in order to develop new broad spectrum antibiotics.Methods: The compounds 3(a-l) were synthesised by reacting the corresponding 2-(aryl)-1H-imidazoles 2 with substituted benzoyl chlorides. Binding mode analysis of the most active compound was carried out. Predictive ADME studies were carried out for all the compounds.Results and Discussions: Among the synthesized compounds, (2-(3-nitrophenyl) (2,4-dichlorophenyl) -1Himidazol-1-yl)methanone 3i exhibited highest antibacterial activity. Binding mode analysis of the highest active compound was carried out in the active site of glucosamine-6-phosphate synthase (2VF5).