Antibacterial Activity Assay From Sintrong Leaf Crassocephalum crepidiodies Against Staphylococcus aureus Bacteria

Sintrong (Crassocephalum crepidioides) is Asteraceae's family plant. In Medan in addition used as a vegetable, sintrong leaves also be used as traditional medicine; among them to cope with stomach disorders, headache, and ulcer scars. The purpose of this research was spesification about characteristic, determination of chemical compounds group and antibacterial activity of ethanol extract, n-heksana fraction, ethylacetate fraction and water fraction of sintrong leaves against Staphylococcus aureus. The sample used was sintrong (Crassocephalum crepidioides) taken from Mupakat Jadi Village, Sub-District Bukit, districts Bener Meriah. This research purposive stages, namely materials plant, identification, preparation and characterization simplisia, determination the class of chemical compounds of simplex, preparation extract and antibacterial activity tested. Test of antibacterial activity by agar diffusion method used paper disc. Parameters measured were inhibition zone of Staphylococcus aureus. Antibacterial activity test results shows are effectivity, with a concentration of 2,5 mg/ml provides inhibition area diameter (9,5 mm) against Staphylococcus aureus bacteria, a concentration of 5 mg/ml provides inhibition area diameter (10,7 mm) to Staphylococcus aureus, a concentration of 7,5 mg/ml provides inhibition area diameter (10,9 mm) to Staphylococcus aureus, and a concentration 10 mg/ml provides inhibition area diameter (11,5 mm) to Staphylococcus aureus.