Open AccessVALUE OF MOLECULAR GENETIC MARKERS IN THE PROGNOSIS OF LOCALLY ADVANCED FORMS OF CERVICAL CANCER
Author(s) -
Nargiza Karimova
Publication year - 2019
Publication title -
black sea scientific journal of academic research
Language(s) - English
Resource type - Journals
ISSN - 2346-7541
DOI - 10.36962/gbssjar4906201924
Subject(s) - cervical cancer , medicine , vegf receptors , oncology , cancer , disease , biopsy , tumor progression , pathology
In biopsy preparations, there are 30 patients with cervical cancer at the IIb-IIIb clinical stages. A study in patients with locally advanced cervical cancer showed that a high expression level of VEGF and Ki67 proliferation in primary patients, elevated levels of p53 protein before carrying out correlate with an unfavorable prognosis, which makes it possible to use these indicators in monitoring the course of the disease. It was shown that prior to the initiation of antitumor treatment, the expression level of VEGF and Ki67 were as high as possible in those patients who subsequently showed progression of the disease, and reached 85%. The expression level of VEGF, Ki67 and p53 protein was shown to correlate with indicators of tumor progression.