Open AccessEffect of 5-HTP and L-Dopa on lipid profile of Streptozotocin induced diabetic mice
Author(s) -
Ulka Yadav,
Rajkumari Batham
Publication year - 2014
Publication title -
environment conservation journal/environment conservation journal
Language(s) - English
Resource type - Journals
eISSN - 2278-5124
pISSN - 0972-3099
DOI - 10.36953/ecj.2014.15324
Subject(s) - endocrinology , medicine , streptozotocin , cholesterol , diabetes mellitus , triglyceride , dopamine , insulin , hemoglobin , lipid profile , serotonin , very low density lipoprotein , high cholesterol , chemistry , lipoprotein , receptor
The present study was designed to test whether the precursor of serotonin (i.e.5-HTP) and dopamine (i.e. L-DOPA) can influence Body weight and certain hematological constitutes (i.e. blood glucose, glycosylated hemoglobin and serum protein) in streptozotocin induced diabetic mice. In the study, animals were divided into 6 groups. After 10 days at the termination of experiment body weight and blood glucose taken. Blood was collected from left ventricle and deposited to pathology for haematological analysis (i.e. blood Glucose, glycosylated heamoglobin, serum protein, triglyceride total cholesterol, HDL-cholesterol, LDC-cholesterol, and VLDL-cholesterol). Statistical analysis were done with the help of student’s ‘t’ test followed by analysis of variance (ANOVA). The result of the present study suggest that peripheral administration of 5-HTP (a precursor of serotonin) and L-DOPA (a precursor of dopamine) influences the body weight gain and lipid profile (i.e. triglyceride, total cholesterol, HDL-cholesterol , LDL-Cholesterol, VLDC-cholesterol) in streptozotocin induce diabetic mice. The finding of the present study supports the concept that insulin alone does not fully control diabetes. Other chemical substance like neurotransmitter/hormones may involve in controlling the diabetes.