Open AccessExperimental studies on leucocyte response in contact dermatitis induced by calcium chromate
Author(s) -
Vibha Dube
Publication year - 2014
Publication title -
environment conservation journal/environment conservation journal
Language(s) - English
Resource type - Journals
eISSN - 2278-5124
pISSN - 0972-3099
DOI - 10.36953/ecj.2014.15313
Subject(s) - contact dermatitis , eosinophil , immunology , degranulation , basophil , calcium , allergic contact dermatitis , monocyte , chromate conversion coating , levamisole , lymphocyte , granulocyte , chemistry , medicine , allergy , chromium , immunoglobulin e , asthma , antibody , receptor , organic chemistry
Contact dermatitis was induced in mice by injecting various concentrations of calcium chromate through subcutaneous route. Leucocyte response in these experimental mice was assessed on the basis of increase/decrease in total and differential counts which significantly differed as compared to those of respective controls. Total leucocyte counts increased significantly. A remarkable increase was also observed in lymphocyte, monocyte and eosinophil counts. Neutrophil and basophil counts decreased in the test groups. It emphasizes that contact dermatitis induced by chromium is delayed hypersensitivity reaction and is mediated through the sensitized cells. Pharmacological mediators released following degranulation of these cells play an important role in allergic reactions.