Open AccessTOXIC PULMONARY EDEMA BY INHALATION OF PYROLYSIS PRODUCTS OF CHLORINATED PARAFFIN-70 IN RATS
Author(s) -
П. Г. Толкач,
Vadim A. Basharin,
С. В. Чепур
Publication year - 2018
Publication title -
toksikologičeskij vestnik
Language(s) - English
Resource type - Journals
ISSN - 0869-7922
DOI - 10.36946/0869-7922-2018-6-8-11
Subject(s) - pulmonary edema , inhalation , hypoxemia , edema , medicine , lung , anesthesia , respiratory failure , respiratory system , toxicology , biology
In the study conducted on laboratory animals (rats) toxic pulmonary edema (TPE) was simulated by inhalation of pyrolysis products of chlorinated paraffin-70 (CP-70). The average-lethal dose of CP-70 burned at 280 ÷ 350 ° C for 3 minutes is 8.1 ± 0.9 g and provides a concentration of hydrogen chloride (HCl) in the chamber at the level of 7325 [5850; 8460] ppm. Under these conditions exposure for 30 minutes led to an increase in the pulmonary rate (LC) in laboratory animals 24 hours after poisoning. The diagnosis of TPE was confirmed histologically by the signs of interstitial and alveolar edema, as well as arterial hypoxemia (TI = 204.5 [180; 228]) indicating respiratory failure. The death of animals was recorded 3 days after application of the pyrolysis products of CP-70. The simulated experimental TPE model can be used to search for the means of pathogenetic therapy of pulmonary toxicants poisoning.