Mathematical model of excitation-contraction in a uterine smooth muscle cell | Zendy

Weiwei Ai | Zendy; Limor Freifeld | Zendy; David Nickerson | Zendy

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Mathematical model of excitation-contraction in a uterine smooth muscle cell

Author(s) -

Weiwei Ai,

Limor Freifeld,

David Nickerson

Publication year - 2021

Publication title -

physiome

Language(s) - English

Resource type - Journals

ISSN - 2744-6204

DOI - 10.36903/physiome.16828756.v1

Subject(s) - myosin , smooth muscle , intracellular , contraction (grammar) , biophysics , muscle contraction , chemistry , excitation , cell , phosphorylation , computer science , myosin light chain kinase , biological system , anatomy , engineering , biology , biochemistry , endocrinology , electrical engineering

The Bursztyn et al. (2007) paper proposes a mathematical model of excitation-contraction in a myometrial smooth muscle cell (SMC). The model incorporates processes of intracellular Ca^2+ concentration control, myosin light chain (MLC) phosphorylation and stress production. We create a modularized CellML implementation of the model, which is able to simulate these processes against the original data.

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