Open AccessMathematical model of excitation-contraction in a uterine smooth muscle cell
Author(s) -
Weiwei Ai,
Limor Freifeld,
David Nickerson
Publication year - 2021
Publication title -
physiome
Language(s) - English
Resource type - Journals
ISSN - 2744-6204
DOI - 10.36903/physiome.16828756.v1
Subject(s) - myosin , smooth muscle , intracellular , contraction (grammar) , biophysics , muscle contraction , chemistry , excitation , cell , phosphorylation , computer science , myosin light chain kinase , biological system , anatomy , engineering , biology , biochemistry , endocrinology , electrical engineering
The Bursztyn et al. (2007) paper proposes a mathematical model of excitation-contraction in a myometrial smooth muscle cell (SMC). The model incorporates processes of intracellular Ca^2+ concentration control, myosin light chain (MLC) phosphorylation and stress production. We create a modularized CellML implementation of the model, which is able to simulate these processes against the original data.