Open AccessGenomic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains isolated in Malaysia
Author(s) -
HooiLeng Ser,
Loh TengHern Tan,
Jodi WoanFei Law,
Vengadesh Letchumanan,
Nurul Syakima Ab Mutalib,
LearnHan Lee
Publication year - 2020
Publication title -
progress in microbes and molecular biology
Language(s) - English
Resource type - Journals
ISSN - 2637-1049
DOI - 10.36877/pmmb.a0000093
Subject(s) - clade , genome , biology , strain (injury) , virulence , highly pathogenic , virology , phylogenetic tree , covid-19 , coronavirus , epidemiology , outbreak , phylogenetics , genetics , gene , virus , medicine , disease , infectious disease (medical specialty) , pathology , influenza a virus subtype h5n1 , anatomy
Using seven complete genomes of human SARS-CoV-2 (retrieved from GISAID) isolated in Malaysia forphylogenetic tree construction, the current study showed that these strains formed four distinct clades when compared with other representative strains from Asia, Europe and US. In light of that, the genome sequences of these strains isolated in Malaysia suggested that there is currently more than one “type” of strain within the country. Complementing with epidemiological and experimental studies, these findings allow better understanding the prevalence of certain types in Malaysia and permits further in-depth studies on the virulence and pathogenic mechanisms of these strains which is particularly critical to speed up the development of effective treatment regime.