Open AccessAcitretin for Secondary Prevention of Keratinocyte Cancers in a Veteran Population: A Retrospective Cohort Study
Author(s) -
Rachel Lim,
Martin A. Weinstock,
Shoshana Landow
Publication year - 2021
Publication title -
journal of drugs in dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 62
ISSN - 1545-9616
DOI - 10.36849/jdd.5721
Subject(s) - medicine , acitretin , retrospective cohort study , dermatology , cohort , keratinocyte , cohort study , population , psoriasis , environmental health , genetics , biology , in vitro
Acitretin, a vitamin A derivative used for psoriasis, can prevent keratinocyte carcinoma (KC). It induced regression of keratoacanthomas (KA) in animal models, presumably by activating retinoic acid and retinoid X receptors that regulate gene expression for growth and proliferation.1,2.