Open AccessPreclinical Study of Nanostructured Cubic Liquid Crystalline Formulating of Ulva Fascista Bioactive Polysaccharides against Hepatocirrhosis
Author(s) -
Azza A. Matloub,
Mona M. AbouSamra,
Alaa H. Salama,
Manal A. Hamed,
Sanaa A. Ali
Publication year - 2021
Language(s) - English
DOI - 10.36811/ojpsr.2021.110012
Subject(s) - polysaccharide , zeta potential , alkaline phosphatase , aqueous solution , chemistry , in vitro , nuclear chemistry , nanoparticle , particle size , drug , chromatography , biochemistry , enzyme , materials science , pharmacology , organic chemistry , nanotechnology , biology
From our previous study, the aqueous soluble polysaccharides isolated from cold aqueous extract of Ulva fascinate was prepared and represented as the most of its bioactive constituents. The polysaccharides were formulated as autosomal nanoparticles for use as anti-hepatocirrhosis drugs. The formulations were characterized by their encapsulation efficiency, particle size, zeta potential and in vitro release. The selected formulation was subjected to a preclinical study. Serum biomarkers enzymes (aspartate and alanine aminotransferases and alkaline phosphatase) were proved the efficacy of the polysaccharides loaded cub some similar to the reference drug; silymarin in addition to its safety on liver. The histopathological examination was conducted to document the biochemical results.