Open AccessIn vitro antimicrobial activity screening of new Heterocyclic compounds derived from 5-bromo-2,3-di(furan-2-yl)-1h-indole
Author(s) -
Hana A. A. Mageed,
Reda F. El- Ezabi,
Fayrouz A. Khaled
Publication year - 2021
Language(s) - English
DOI - 10.36811/jca.2021.110033
Subject(s) - antimicrobial , indole test , chemistry , moiety , pharmacophore , furan , monobasic acid , thiourea , combinatorial chemistry , organic chemistry , stereochemistry
This article describes the antimicrobial activity evaluation of new heterocyclic compounds derived from 5-bromo-2,3-di(furan-2-yl)-1h-indole. Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively attached to produce novel drugs. New compounds were obtained on the basis of derivatives including 1H-indole-2,3-dione derivatives. Acid-catalyzed, three-component reaction (Belinelli synthesis) between 5-bromo-2,3-di(furan-2-yl)1H-indole, acetylacetone and semi carbazide, thiosemicarbazone, urea, thiourea, guanidine constitutes a rapid and facile synthesis of corresponding tetrahydro pyrimidines, which are interesting compounds with a potential for pharmaceutical application. Antimicrobial tests revealed high antibacterial activity of obtained derivatives. The synthesized compounds have been screened for their in vitro antimicrobial activity against various strains of bacteria and fungi.Keywords: Vitro; Heterocyclic Compounds; Antimicrobial