Open AccessInvestigation of DNA Damage Induced by Alkylating Agents and Repair Pathways by Cooperating Mechanisms Driving the Formation of Colorectal Adenomas and Adenocarcinomas Using DNA Alkylation and DNA Methylation
Author(s) -
Elena Locci,
Silvia Raymond
Publication year - 2021
Language(s) - English
DOI - 10.36811/jca.2021.110018
Subject(s) - colorectal cancer , alkylation , dna damage , dna , cancer , dna repair , cancer research , dna methylation , bioinformatics , biology , medicine , chemistry , genetics , gene , biochemistry , gene expression , catalysis
In this recent study, DNA data from 900 patients with colorectal cancer were reviewed. Analysis of the data showed a distinct mutation signature, a pattern that had never been identified before but indicated a type of DNA damage called "alkylation." Red meat contains chemicals that can cause alkylation. High levels of tumor alkylation damage are seen only in patients who consume an average of more than 150 grams of meat per day, roughly equivalent to two or more meals. On the other hand, a group of researchers in 2019 in a controversial conclusion stated that they do not have much confidence in reducing deaths from colon cancer by avoiding red meat.Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management