Open AccessDownregulation of ephrin-B1 is a critical event of podocyte injury
Author(s) -
Yoshiyasu Fukusumi,
Veniamin Ivanov,
Ying Zhang,
Hidenori Yasuda,
Hiroshi Kawachi
Publication year - 2021
Language(s) - English
DOI - 10.36811/cjn.2021.110004
Subject(s) - nephrin , slit diaphragm , podocyte , downregulation and upregulation , microbiology and biotechnology , ephrin , cytoplasm , phosphorylation , pdz domain , biology , proteinuria , signal transduction , endocrinology , kidney , biochemistry , gene
Proteinuria in several glomerular diseases results from dysfunction of the slit diaphragm, a cell-cell junction of glomerular epithelial cells (podocytes). Ephrin-B1 and its related molecule NHERF 2 are novel essential components of the slit diaphragm. Ephrin-B1 interacts with nephrin via the extra-cellular domain and interacts with NHERF2 via the cytoplasmic site. In the proteinuric state induced by the stimulation to nephrin, nephrin and ephrin-B1 are phosphorylated, and NHERF2 is de- phosphorylated and consequent disruption of the linkage and downregulation of nephrin, ephrin-B1 and NHERF2 are a critical pathogenic event of podocyte injury.Keywords: Podocyte; Slit Diaphragm; Ephrin-B1; Nephrin; NHERF2