Open AccessHaemato-biochemical changes following inhalational exposure to commercial grade pyrethroid mixture in male Wistar rats
Author(s) -
Okediran,
Ajayi,
Adah,
Biobaku,
Vojtěch Adam,
. Sanusi
Publication year - 2018
Publication title -
savannah veterinary journal
Language(s) - English
Resource type - Journals
ISSN - 2636-6150
DOI - 10.36759/svj.2017.011
Subject(s) - pyrethroid , creatinine , urea , mean corpuscular volume , physiology , alanine aminotransferase , zoology , toxicology , biology , chemistry , medicine , endocrinology , biochemistry , hemoglobin , pesticide , agronomy
Pyrethroid insecticides are widely used for control of insects such as ticks and flies which may act as disease vectors. During usage, these pyrethroids are absorbed not only by the target parasites but also by the host. We investigated the haematological and some biochemical changes that may occur as a result of daily exposure to pyrethroids via inhalation for seven days in male Wistar rats at varying concentrations.Methods: A total of sixteen male Wistar rats used for this investigation were divided into four groups: A-D. Group A served as the control unexposed while groups B-D were exposed to 0.04; 0.08 and 0.16mg/ml of pyrethroid (0.05% imiprothrin, 0.05% prallethrin and 0.015% cyfluthrin) respectively daily for seven days.Results: The results showed a significant reduction in packed cell volume, mean corpuscular haemoglobin and haemoglobin concentrations, while there was also a significant increase (p < 0.05) in activities of aspartate aminotransferase and alanine aminotransferase while protein, creatinine and urea concentrations were equally elevated.Significance: Repeated exposure to pyrethroid continuously over a period of seven days resulted in alteration of haematological and biochemical parameters predisposing the rats to microcytic hypochromic anaemia and perturbation of protein metabolism.