Open AccessFUNCTIONING OF NO-CYCLE IN THE ORAL FLUID IN CHILDREN OF PRIMARY SCHOOL AGE WITH TYPE 1 DIABETES MELLITUS IN THE TREATMENT OF CHRONIC CATARRHAL GINGIVITIS
Author(s) -
Ольга Вікторівна Шешукова,
Iryna O. Kuz,
Віталій Олександрович Костенко,
Oleg Ye. Akimov,
A. I. Maksymenko,
O. A. Pysarenko,
Natalia A. Lyakhova
Publication year - 2022
Publication title -
wiadomości lekarskie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.133
H-Index - 14
eISSN - 2719-342X
pISSN - 0043-5147
DOI - 10.36740/wlek202203116
Subject(s) - gingivitis , medicine , type 2 diabetes mellitus , diabetes mellitus , arginase , gastroenterology , endocrinology , dentistry , arginine , biology , biochemistry , amino acid
The aim: To determine the activity of NO-synthase and arginase in oral fluid in children with type 1 diabetes mellitus and to evaluate the efficacy of the treatment scheme we elaborated in the treatment of chronic catarrhal gingivitis.Materials and methods: 82 children were examined, they were divided into groups by presence of gingivitis and diabetes mellitus. NO-synthase (NOS) activity was determined in oral fluid by the difference in nitrite concentration before and after incubation. The arginase activity was determined in oral fluid by the difference in the concentration of L-ornithine before and after incubation.Results: Use our treatment scheme in children with chronic catarrhal gingivitis and type 1 diabetes mellitus lead to a change in the polarization of oral macrophages towards the predominance of M2 polarization in 1 month. The polarization of macrophages changed to the predominance of M1 polarization activity in 1 year.Conclusions: We have elaborated a scheme for the treatment of chronic catarrhal gingivitis in children with type 1 diabetes mellitus. It normalizes the polarization of oral macrophages caused by exposure to chronic catarrhal gingivitis as a local pathogenetic factor.