Open AccessIMMUNODIAGNOSIS IN MEMBRANOUS NEPHROPATHY
Author(s) -
Magdalena Ratajczak,
Ewa Poleszak,
Tomasz Chrościcki
Publication year - 2020
Publication title -
wiadomości lekarskie
Language(s) - English
Resource type - Journals
eISSN - 2719-342X
pISSN - 0043-5147
DOI - 10.36740/wlek202009110
Subject(s) - membranous nephropathy , anti nuclear antibody , antibody , medicine , immunology , pathology , antigen , glomerulonephritis , autoantibody , kidney
One of the diseases leading to chronic end-stage renal disease is membranous nephropathy (MN). The main cause of this disease is the formation of antibodies to foreign and native antigens. Membranous nephropathy can be conventionally divided into 2 types: primary form (when the primary disease is unknown) and secondary form. Detection of appropriate antibodies is one of the methods to recognize and differentiate primary and secondary forms. A large role in non-invasive diagnosis of MN and differentiation of the primary form from the secondary play antinuclear antibodies (ANA), antibodies against granulocyte cytoplasm (ANCA), antiglomerular basement antibodies (anti-GBM) and phospholipase A2 receptor antibodies (anti-PLA2R). Differentiation matters when choosing a treatment choice. In the primary form, it is immunosuppression, and in the form of secondary treatment, it consists in curing or controlling diseases that can cause symptoms of MN.The aim: Analysis of serological methods helpful in immunodiagnosis of membranous nephropathy.