Open AccessPECULIAIRITIES OF THE FUNCTIONING CIRCADIAN ORGANIZATION THE ION-REGULATING FUNCTION OF KIDNEY UNDER THE CONDITION OF PINEAL GLAND HYPERFUNCTION OF THE INFLUENCE NITROGEN MONOXIDE SYNTHESIS BLOCKADE
Author(s) -
S. B. Semenenko,
S. Yu. Karatieieva,
Оксана Валеріанівна Бакун,
K. V. Slobodian,
Oksana Ivanivna Yurkiv
Publication year - 2019
Publication title -
wiadomości lekarskie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.133
H-Index - 14
eISSN - 2719-342X
pISSN - 0043-5147
DOI - 10.36740/wlek201902117
Subject(s) - hyperfunction , blockade , circadian rhythm , kidney , endocrinology , medicine , pineal gland , adrenal gland , monoxide , chemistry , function (biology) , biology , microbiology and biotechnology , receptor , inorganic chemistry
The aim of our work was to investigate the peculiarities of the functioning circadian organization the ion-regulating function of pineal gland hyperfunction of the influencenitrogen monoxide synthesis blockade.Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The control group included animals(n=36) kept under conditions of usual light regimen (12.00L:12.00D) during 7 days. The experimental group included animals (n=36) injected with N-nitro-L-arginine (L-NNA)in the dose of 20 mg/kg during 7 days under conditions of continuous absolute darkness (12.00D:12.00D). On the 8th day the animals were exposed to 5% water load with heatedto room temperature water supplied and the parameters of the kidney ion-regulating function under conditions of forced diuresis were investigated.Results and conclusions: The obtained results of the performed blockade nitrogen monoxide (NO) synthesis in conditions of hyperfunction of the brain epiphysis allow toconclude that the daily mean of the rate of excretion of sodium ions decreases in comparison with the animals that were kept under pineal gland (PG) hyperfunction of thefiltration fraction and reabsorption of sodium ions are reduced compared to the control animals and rats which were kept under conditions of PG hyperfunction and accompaniedby stable indicators of the concentration the specified cation in the blood plasma during the observation period. The action of the blockade NO synthesis in conditions of PGhyperfunction leads to a decrease in the distal transport bridge of sodium ions with a maximum in the day and night intervals of the day the position of the acro- and batiphaseof the rhythm changes as compared with the control animals.