Open AccessEffects of Prophylactic Use of a Decoction of Blueberry Leaves in Modeling the Lesion of the Gastrointestinal Tract by Non-Steroidal Anti-Inflammatory Drugs
Author(s) -
Alisa V. Pachevska,
Alina V. Biloshitska,
Valery M. Istoshyn
Publication year - 2020
Publication title -
acta balneologica
Language(s) - English
Resource type - Journals
ISSN - 2082-1867
DOI - 10.36740/abal202004107
Subject(s) - decoction , medicine , stomach , periodontitis , gastrointestinal tract , lesion , traditional medicine , duodenum , pharmacology , gastroenterology , surgery
Introduction: Today there is a continuing search for an effective, affordable remedy that can be used to treat and prevent diseases of periodontal, stomach and duodenum during the use non-steroidal anti-inflammatory drugs ( NSAIDs ).Aim: To study the protective effect of phytopreparation (decoction of blueberry leaves) on an experimental model of gastric ulcer and periodontitis.Material and Methods: The study was performed on 30 rats, which were evenly divided into three groups: 1 – control animals, 2 – animals that were modeled with non-steroid gastric ulcer and periodontitis (7 mg/kg diclofenacum natrium intragastrically for 5 days) and 3 – group in the background experimental pathology was introduced decoction of blueberry leaves 1:10 2 ml intragastrically (30 minutes after the introduction of diclofenacum natrium).Results: Histological examination of the mucous membrane of rats, which used as a preventive agent decoction of blueberry leaves, showed that it is characterized only by single erosion, no fibrinosis and hemorrhagic plaque, lympho-macrophage infiltration.Conclusions: Simultaneous use of a decoction of blueberry leaves can be used as a preventive and curative agent to prevent the development of erosions and ulcers of the mucous membrane of the digestive system.