Open AccessActivated zinc pyrithione. Mechanism of action. Clinical application
Author(s) -
Yu K Skripkin,
F I Petrovskiy,
Е С Феденко,
А Н Пампура,
Д. С. Коростовцев,
P C Fassa khov,
E O Sukmanskaya,
Yu K Skripkin,
F I Petrovskiy,
Е С Феденко,
А Н Пампура,
Д. С. Коростовцев,
R S Fassahov,
E O Sukmanskaja
Publication year - 2007
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja98
Subject(s) - psoriasis , atopic dermatitis , medicine , dermatology , mechanism of action , nonsteroidal , broad spectrum , epidermis (zoology) , immunology , allergy , pharmacology , chemistry , biochemistry , in vitro , combinatorial chemistry , anatomy
Activated zinc pyrithione (ZP) has a number of contributory pharmacodynamic effects that provide it's efficacy in psoriasis and atopic dermatitis. Because of ZP impairs the integrity of cell membranes it is active against many bacterial and yeast species. In psoriasis and atopic dermatitis ZP therapy is accompanied by accelerated cells' apoptosis of lower layers of epidermis and atopic inflammatory infiltrate as well as by decrease in skin neutrophils and lymphocytes. The broad spectrum of pharmacological activities together with wide clinical experience worldwide endorse activated ZP as effective and safe nonsteroidal medication for topical therapy of different dermatoses and support it's use in dermatology, paediatrics and allergy.