Open AccessTHE CLINICAL DISPLAYS AND THE FUNCTIONAL ACTIVITYOF RIBOSOMAL GENES IN ASTHMATIC CHILDREN
Author(s) -
В. П. Иванов,
N V Stabrovskaya,
Andreas Blum,
Е. В. Трубникова,
В. П. Иванов,
N V Stabrovskaya,
Andreas Blum,
Е. В. Трубникова
Publication year - 2010
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja889
Subject(s) - ribosomal rna , ribosomal protein , gene , 5s ribosomal rna , biology , genetics , 18s ribosomal rna , ribosome , rna
Background. To analyze the interrelations between the parameters of the functional activity of ribosomal genes and some clinical features in asthmatic children.Material and methods. 78 asthmatic patients were included in the study. Standard methods of production and colouring of cytogenetic preparations were used. The functional activity of ribosomal genes was defined on five-pointsystem in arbitrary units. Statistical data processing was spent with the help of applied programs Statistica 6.0.Results. The data about the level of the functional activity of ribosomal genes of asthmatic children (18,57 arbitraryunits) were obtained. In all patients the general functional activity of ribosomal genes parameters were correlatedwith the number of leukocytes and the functional activity of ribosomal genes localized in GHchromosomes parameter -with the level of immunoglobulin E. We constructed the discrimination model according to the disease severityindex which included 4 significant parameters: bands number, disease manifestation age, blood sedimentation rateand active ribosomal genes copies number.Conclusion. Our data give evidence about the interrelations between the functional activity of ribosomal genes parameters and some clinical features in asthmatic children. The number of active ribosomal genes copies is consideredto be one of the significant features of disease activity.