Open AccessAssessment of antimicrobial peptides(alpha-defensins) in atopic dermatitis and pyodermia patients blood
Author(s) -
Е А Цывкина,
Е С Феденко,
А С Будихина,
Б В Пинегин
Publication year - 2009
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja887
Subject(s) - atopic dermatitis , medicine , immunology , beta defensin , defensin , alpha (finance) , antimicrobial peptides , allergy , peripheral blood , antimicrobial , immune system , microbiology and biotechnology , biology , innate immune system , surgery , construct validity , patient satisfaction
The purpose of research. The purpose was to investigate alpha-defensin levels in the circularly neutrophiles of atopic dermatitis and pyodermia patients in comparison with healthy donors.Materials and methods. 27 patients with atopic dermatitis, 31 patients with pyodermia in comparison with 17 healthy donors were investigated. Intracellular alpha-defensin levels in neutrophils in the peripheral blood were estimated by flow cytometry with mouse anti-HNP-antibodies (Hy cult biotechnology).Results. The alpha-defensins level in patients with atopic dermatitis and pyodermia was reduced in comparison with healthy donors. More expressed decrease of alpha-defensins level was obtained in patients with pyodermia and sever atopic dermatitis with skin infection.Conclusion. Thus, a decrease of alpha-defensins levels in atopic dermatitis and pyodermia patients, possibly, is a marker of the chronic bacterial inflammation and may cause chronic bacterial skin disease, St. aureus colonizations and tolerance to the therapy.